Microglia LILRB4 upregulation reduces brain damage after acute ischemic stroke by limiting CD8⁺ T cell recruitment.

ABSTRACT:

Background

Leukocyte immunoglobulin-like receptor B4 (LILRB4) plays a significant role in regulating immune responses. LILRB4 in microglia might influence the infiltration of peripheral T cells. However, whether and how LILRB4 expression aggravates brain damage after acute ischemic stroke remains unclear. This study investigates the role of LILRB4 in modulating the immune response and its potential protective effects against ischemic brain injury in mice.

Methods and results

Microglia-specific LILRB4 conditional knockout (LILRB4-KO) and overexpression transgenic (LILRB4-TG) mice were constructed by a Cre-loxP system. Then, they were used to investigate the role of LILRB4 after ischemic stroke using a transient middle cerebral artery occlusion (tMCAO) mouse model. Spatial tra

SUBMITTER: Ma Y 

PROVIDER: S-EPMC11366150 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature