Beyond 2D cell cultures: how 3D models are changing the in vitro study of ovarian cancer and how to make the most of them.

ABSTRACT: 3D cell cultures are a fundamental tool in ovarian cancer research that can enable more effective study of the main features of this lethal disease, including the high rates of recurrence and chemoresistance. A clearer, more comprehensive understanding of the biological underpinnings of these phenomena could aid the development of more effective treatments thus improving patient outcomes. Selecting the most appropriate model to investigate the different aspects of cell biology that are relevant to cancer is challenging, especially since the assays available for the study of 3D cultures are not fully established yet. To maximise the usefulness of 3D cell cultures of ovarian cancer, we undertook an in-depth review of the currently available models, taking into consideration the strengths and

SUBMITTER: Cortesi M 

PROVIDER: S-EPMC11366228 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature