Development of a Slow-Degrading Polymerized Curcumin Coating for Intracortical Microelectrodes.

ABSTRACT: Intracortical microelectrodes are used with brain-computer interfaces to restore lost limb function following nervous system injury. While promising, recording ability of intracortical microelectrodes diminishes over time due, in part, to neuroinflammation. As curcumin has demonstrated neuroprotection through anti-inflammatory activity, we fabricated a 300 nm-thick intracortical microelectrode coating consisting of a polyurethane copolymer of curcumin and polyethylene glycol (PEG), denoted as poly(curcumin-PEG₁₀₀₀ carbamate) (PCPC). The uniform PCPC coating reduced silicon wafer hardness by two orders of magnitude and readily absorbed water within minutes, demonstrating that the coating is soft and hydrophilic in nature. Using an in vitro release model, curcumin eluted from the

SUBMITTER: Ziemba AM 

PROVIDER: S-EPMC11366415 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature