Multi-compartment V/Q lung modeling: Log normal distributions of inspired or expired alveolar gas?

ABSTRACT: Using a 50-compartment Python-coded mathematical lung model, we compared mixed venous blood flow (Q) distributions and arterial oxygen tension/inspired oxygen fraction (PaO₂/FiO₂) relationships in lungs modeled with log normal distributions (LND) of inspired (V_I) versus expired (V_A) alveolar gas volumes. In lungs with normal V/Q heterogeneity, Q versus V_A/Q and Q versus V_I/Q distributions were similar with either approach, and PaO₂/FiO₂ sequences remained indistinguishable. In V/Q heterogeneous lungs at high FiO₂, V_ILND generated low Q versus V_A/Q shoulders and some negative V_A units, while V_ALND preserved Q versus V_A/Q log normality by b

SUBMITTER: Scott PH 

PROVIDER: S-EPMC11366441 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature