Sortilin is associated with progranulin deficiency and autism-like behaviors in valproic acid-induced autism rats.

ABSTRACT:

Introduction

Neuroinflammation and microglial activation-related dendritic injury contribute to the pathogenesis of Autism Spectrum Disorder (ASD). Previous studies show that Progranulin (PGRN) is a growth factor associated with inflammation and synaptic development, but the role of PGRN in autism and the mechanisms underlying changes in PGRN expression remain unclear.

Aims

To investigate the impact of PGRN in autism, we stereotactically injected recombinant PGRN into the hippocampus of ASD model rats. Additionally, we explored the possibility that sortilin may be the factor behind the alterations in PGRN by utilizing SORT1 knockdown. Ultimately, we aimed to identify potential targets for the treatment of autism.

Results

PGRN could alleviate inflammatory responses, pr

SUBMITTER: Liao A 

PROVIDER: S-EPMC11366450 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature