RNF122 promotes glioblastoma growth via the JAK2/STAT3/c-Myc signaling Axis.

ABSTRACT:

Objective

The E3 ubiquitin ligase is well recognized as a significant contributor to glioblastoma (GBM) progression and has promise as a prospective therapeutic target. This study explores the contribution of E3 ubiquitin ligase RNF122 in the GBM progression and the related molecular mechanisms.

Methods

RNF122 expression levels were evaluated using qRT-PCR, WB, and IHC, while functional assays besides animal experiments were used to assess RNF122's effect on GBM progression. We also tested the RNF122 impact on JAK2/STAT3/c-Myc signaling using WB.

Results

RNF122 was upregulated in GBM and correlated to the advanced stage and poor clinical outcomes, representing an independent prognostic factor. Based on functional assays, RNF122 promotes GBM growth and cell cycle, whic

SUBMITTER: Xiao Q 

PROVIDER: S-EPMC11366496 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature