Clinicopathologic significance of heat shock protein 60 as a survival predictor in breast carcinoma.

ABSTRACT:

Background

While Heat Shock Protein 60 (HSP60) has been linked to human tumor, its clinic significance specifically in breast carcinoma is unclear. This investigation aims to retrospectively evaluate how HSP60 protein levels relate to survival outcomes among patients diagnosed with breast carcinoma.

Methods

Evaluation of 206 patients diagnosed with breast carcinoma and receiving treatment from January 2012 to April 2018, carried out retrospectively. The protein level of HSP60 in breast carcinoma determined by immunohistochemical.

Results

The study provided evidence of a distinct upregulation of HSP60 expression in breast carcinoma tumor samples in contrast to adjacent normal tissue samples. Additionally, heightened HSP60 expression was linked to advanced T stage (P =

SUBMITTER: Wang Q 

PROVIDER: S-EPMC11366582 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature