The effects of exercise on microRNA expression profiling in adipose tissue macrophages of mice.

ABSTRACT:

Background

Exercise is recognized for its broad health benefits, influencing various physiological processes, including the behavior of adipose tissue macrophages (ATMs). While existing studies mainly associate ATM activity with obesity and metabolic syndrome, our study explores the impact of aerobic exercise on ATM microRNA expression profiling in a non-obese context, highlighting its general health-promoting mechanisms.

Methods

Sixty male C57BL/6 mice were randomly assigned to either a sedentary (S) or an exercise (E) group. The S group remained inactive, while the E group underwent a one-week treadmill adaptation, followed by an 8-week aerobic treadmill exercise protocol (60 min/day, 5 days/week, at 65%-75% VO_2max). Post-training, glucose tolerance and the seru

SUBMITTER: Qin F 

PROVIDER: S-EPMC11366585 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature