Transcranial direct current stimulation and neuronal functional connectivity in MCI: role of individual factors associated to AD.

ABSTRACT:

Background

Alzheimer's disease (AD) encompasses a spectrum that may progress from mild cognitive impairment (MCI) to full dementia, characterized by amyloid-beta and tau accumulation. Transcranial direct current stimulation (tDCS) is being investigated as a therapeutic option, but its efficacy in relation to individual genetic and biological risk factors remains underexplored.

Objective

To evaluate the effects of a two-week anodal tDCS regimen on the left dorsolateral prefrontal cortex, focusing on functional connectivity changes in neural networks in MCI patients resulting from various possible underlying disorders, considering individual factors associated to AD such as amyloid-beta deposition, APOE ϵ4 allele, BDNF Val66Met polymorphism, and sex.

Methods

In a

SUBMITTER: Kang DW 

PROVIDER: S-EPMC11366601 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature