Abnormal large-scale resting-state functional networks in anti-N-methyl-D-aspartate receptor encephalitis.

ABSTRACT:

Background

Patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis often experience severe symptoms. Resting-state functional MRI (rs-fMRI) has revealed widespread impairment of functional networks in patients. However, the changes in information flow remain unclear. This study aims to investigate the intrinsic functional connectivity (FC) both within and between resting-state networks (RSNs), as well as the alterations in effective connectivity (EC) between these networks.

Methods

Resting-state functional MRI (rs-fMRI) data were collected from 25 patients with anti-NMDAR encephalitis and 30 healthy controls (HCs) matched for age, sex, and educational level. Changes in the intrinsic functional connectivity (FC) within and between RSNs were analyzed using i

SUBMITTER: Gong X 

PROVIDER: S-EPMC11366611 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature