Physical activity, sedentary behavior, and risk of sepsis: a two-sample mendelian randomization study.

ABSTRACT:

Objective

This investigation aimed to explore the potential causal relationship between physical activity, sedentary behavior and the risk of sepsis.

Methods

Using a two-sample Mendelian randomization approach, this study evaluated the association between physical activity (including moderate to vigorous physical activity [MVPA], vigorous physical activity [VPA], and accelerometer assessed physical activity) and sedentary behaviors (including television watching, computer use, and driving) with the risk of sepsis. This assessment was based on whole-genome association study data from the UK Biobank and the FinnGen database. Causal inferences were estimated using inverse variance-weighted, weighted median, and MR-Egger methods. Sensitivity analyses were performed using Cochran

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11366612 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature