Investigating genomic diversity of Staphylococcus aureus associated with pediatric atopic dermatitis in South Africa.

ABSTRACT:

Importance

Staphylococcus aureus frequently colonizes the skin and nose of patients with atopic dermatitis (AD), a disease associated with skin barrier dysfunction and chronic cutaneous inflammation. Published genomic studies on AD-associated S. aureus in pediatric populations in sub-Saharan Africa are limited.

Objectives

To investigate the phenotypic and genomic diversity of S. aureus in children with and without AD during early childhood.

Data setting and participants

A cross-sectional study of 220 children (aged 9-38 months) with AD (cases) and without AD (controls) from Cape Town and Umtata, South Africa.

Main outcomes and measures

S. aureus phenotypic and genomic diversity were investigated using whole-genome sequencing, antibio

SUBMITTER: Ndhlovu GON 

PROVIDER: S-EPMC11366657 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature