A double-blind intervention trial in healthy women demonstrates the beneficial impact on Bifidobacterium with low dosages of prebiotic galacto-oligosaccharides.

ABSTRACT:

Introduction

Galacto-oligosaccharides (GOS) are well-substantiated prebiotic substrates. Multiple studies have demonstrated a positive impact of GOS on gut microbiota composition and activity, so-far mainly related to Bifidobacterium. However, data on the beneficial impact at lower dosages in a healthy female population are limited. The primary aim of the current study was to reveal the effect of low dosages (1.3 and 2.0 g) of GOS on fecal Bifidobacterium abundance in healthy women. Other outcomes included the effect of low dosage of GOS on overall fecal microbiota composition and on self-perceived GI comfort, sleep quality and mental wellbeing.

Method

Eighty-eight healthy women (42-70 years, BMI 18.7-30 kg/m²) were included in this randomized, paral

SUBMITTER: Looijesteijn E 

PROVIDER: S-EPMC11366710 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature