Bifidobacterium pseudonumeratum W112 alleviated depressive and liver injury symptoms induced by chronic unpredictable mild stress via gut-liver-brain axis.

ABSTRACT:

Introduction

Several studies indicated that depression is associated with liver injury. The role of probiotics in alleviating depression is focused on improving the abnormalities of the central nervous system through the gut-brain axis, while the effect on liver injury is still unclear. The aim of this study was to elucidate the potential link between the antidepressant effect of a potential probiotic strain Bifidobacterium pseudocatenulatum W112 and its effect on alleviating liver injury.

Methods

The 4-week-old Kunming mice were exposed to chronic stress for 4 weeks to establish a depression model.

Results

The depression-like behavior and related biomakers in chronic unpredictable mild stress (CUMS) mice were altered by supplemented with W112 for 2 weeks. Mean

SUBMITTER: Zhao J 

PROVIDER: S-EPMC11366711 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature