Identifying the plasma metabolome responsible for mediating immune cell action in severe COVID-19: a Mendelian randomization investigation.

ABSTRACT:

Introduction

The immune response regulates the severity of COVID-19 (sCOVID-19). This study examined the cause-and-effect relationship between immune cell traits (ICTs) and the risk of severe COVID-19. Additionally, we discovered the potential role of plasma metabolome in modulating this risk.

Methods

Employing data from a genome-wide association study (GWAS), we conducted a two-sample Mendelian randomization (MR) assessment of 731 genetic ICTs and sCOVID-19 (5,101 cases, 1,383,241 controls) incidence. The MR analysis was utilized to further quantitate the degree of plasma metabolome-mediated regulation of immune traits in sCOVID-19.

Results

The inverse variance weighted method recognized 2 plasma metabolites (PMs) responsible for casual associations between immune ce

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11366714 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature