Causality between autoimmune diseases and breast cancer: a two-sample Mendelian randomization study in a European population.

ABSTRACT:

Background

The incidence of autoimmune diseases and breast cancer is significantly higher in women compared to men. Previous observational studies have not conclusively determined the relationship between these two conditions. This study utilizes the Mendelian randomization approach to investigate the genetic association between autoimmune diseases and breast cancer.

Method

Two-sample Mendelian randomization was conducted on a European population using the GWAS database. The inverse variance-weighted method served as the primary analytical approach. The MR-PRESSO test was applied to detect horizontal pleiotropy. To ensure result robustness, the FDR correction method was used.

Result

The study revealed that Sjögren's syndrome lowers the overall risk of breast cancer (O

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11366734 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature