DCC, a potential target for controlling fear memory extinction and hippocampal LTP in male mice receiving single prolonged stress.

ABSTRACT: Post-traumatic stress disorder (PTSD) is a severe stress-dependent psychiatric disorder characterized by impairment of fear memory extinction; however, biological markers to determine impaired fear memory extinction in PTSD remain unclear. In male mice with PTSD-like behaviors elicited by single prolonged stress (SPS), 19 differentially expressed proteins in the hippocampus were identified compared with controls. Among them, a biological macromolecular protein named deleted in colorectal cancer (DCC) was highly upregulated. Specific overexpression of DCC in the hippocampus induced similar impairment of long-term potentiation (LTP) and fear memory extinction as observed in SPS mice. The impairment of fear memory extinction in SPS mice was improved by inhibiting the function of hippocampal D

SUBMITTER: Yang S 

PROVIDER: S-EPMC11366904 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature