PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation.

ABSTRACT:

Objective

The skeleton is one of the largest organs in the body, wherein metabolism is integrated with systemic energy metabolism. However, the bioenergetic programming of osteocytes, the most abundant bone cells coordinating bone metabolism, is not well defined. Here, using a mouse model with partial penetration of an osteocyte-specific PPARG deletion, we demonstrate that PPARG controls osteocyte bioenergetics and their contribution to systemic energy metabolism independently of circulating sclerostin levels, which were previously correlated with metabolic status of extramedullary fat depots.

Methods

In vivo and in vitro models of osteocyte-specific PPARG deletion, i.e. Dmp1^CrePparγ^flfl male and female mice (γOT^KO) and MLO-Y4 osteocyte-like

SUBMITTER: Baroi S 

PROVIDER: S-EPMC11367276 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature