Immune modulatory microRNAs in tumors, their clinical relevance in diagnosis and therapy.

ABSTRACT: The importance of the immune system in regulating tumor growth by inducing immune cell-mediated cytotoxicity associated with patients' outcomes has been highlighted in the past years by an increasing life expectancy in patients with cancer on treatment with different immunotherapeutics. However, tumors often escape immune surveillance, which is accomplished by different mechanisms. Recent studies demonstrated an essential role of small non-coding RNAs, such as microRNAs (miRNAs), in the post-transcriptional control of immune modulatory molecules. Multiple methods have been used to identify miRNAs targeting genes involved in escaping immune recognition including miRNAs targeting CTLA-4, PD-L1, HLA-G, components of the major histocompatibility class I antigen processing machinery (APM) as we

SUBMITTER: Vaxevanis C 

PROVIDER: S-EPMC11367391 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature