Variable positive end-expiratory pressure in an experimental model of acute respiratory distress syndrome: an advanced ventilation modality.

ABSTRACT:

Background

Introducing variability in tidal volume, ventilatory frequency, or both is beneficial during mechanical ventilation in acute respiratory distress syndrome (ARDS). We investigated whether applying cycle-by-cycle variability in the positive end-expiratory pressure (PEEP) exerts beneficial effect on lung function in a model of ARDS.

Methods

Rabbits with lung injury were randomly allocated to receive mechanical ventilation for 6 h by applying a pressure-controlled mode with constant PEEP of 7 cm H₂O (PC group: n=6) or variable PEEP (VEEP) with a coefficient of variation of 21.4%, range 4-10 cm H₂O (PC-VEEP group; n=6). Lung oxygenation index (Pao₂/FiO₂) after 6 h of ventilation (H6) was the primary outco

SUBMITTER: Sudy R 

PROVIDER: S-EPMC11367518 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature