Joint modeling of human cortical structure: Genetic correlation network and composite-trait genetic correlation.

ABSTRACT: Heritability and genetic covariance/correlation quantify the marginal and shared genetic effects across traits. They offer insights on the genetic architecture of complex traits and diseases. To explore how genetic variations contribute to brain function variations, we estimated heritability and genetic correlation across cortical thickness, surface area, and volume of 33 anatomically predefined regions in left and right hemispheres, using summary statistics of genome-wide association analyses of 31,968 participants in the UK Biobank. To characterize the relationships between these regions of interest, we constructed a genetic network for these regions using recursive two-way cut-offs in similarity matrices defined by genetic correlations. The inferred genetic network matches the brain lob

SUBMITTER: Shen J 

PROVIDER: S-EPMC11367654 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature