Polyoxometalate inhibition of SOX2-mediated tamoxifen resistance in breast cancer.

ABSTRACT:

Background

Increased cancer stem cell (CSC) content and SOX2 overexpression are common features in the development of resistance to therapy in hormone-dependent breast cancer, which remains an important clinical challenge. SOX2 has potential as biomarker of resistance to treatment and as therapeutic target, but targeting transcription factors is also challenging. Here, we examine the potential inhibitory effect of different polyoxometalate (POM) derivatives on SOX2 transcription factor in tamoxifen-resistant breast cancer cells.

Methods

Various POM derivatives were synthesised and characterised by infrared spectra, powder X-ray diffraction pattern and nuclear magnetic resonance spectroscopy. Estrogen receptor (ER) positive breast cancer cells, and their counterparts, which h

SUBMITTER: Aurrekoetxea-Rodriguez I 

PROVIDER: S-EPMC11367752 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature