CAIM: coverage-based analysis for identification of microbiome.

ABSTRACT: Accurate taxonomic profiling of microbial taxa in a metagenomic sample is vital to gain insights into microbial ecology. Recent advancements in sequencing technologies have contributed tremendously toward understanding these microbes at species resolution through a whole shotgun metagenomic approach. In this study, we developed a new bioinformatics tool, coverage-based analysis for identification of microbiome (CAIM), for accurate taxonomic classification and quantification within both long- and short-read metagenomic samples using an alignment-based method. CAIM depends on two different containment techniques to identify species in metagenomic samples using their genome coverage information to filter out false positives rather than the traditional approach of relative abundance. In additi

SUBMITTER: Acheampong DA 

PROVIDER: S-EPMC11367759 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature