SnapHiC-G: identifying long-range enhancer-promoter interactions from single-cell Hi-C data via a global background model.

ABSTRACT: Harnessing the power of single-cell genomics technologies, single-cell Hi-C (scHi-C) and its derived technologies provide powerful tools to measure spatial proximity between regulatory elements and their target genes in individual cells. Using a global background model, we propose SnapHiC-G, a computational method, to identify long-range enhancer-promoter interactions from scHi-C data. We applied SnapHiC-G to scHi-C datasets generated from mouse embryonic stem cells and human brain cortical cells. SnapHiC-G achieved high sensitivity in identifying long-range enhancer-promoter interactions. Moreover, SnapHiC-G can identify putative target genes for noncoding genome-wide association study (GWAS) variants, and the genetic heritability of neuropsychiatric diseases is enriched for single-nucleo

SUBMITTER: Liu W 

PROVIDER: S-EPMC11367764 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature