Causal associations of hypothyroidism with frozen shoulder: a two-sample bidirectional Mendelian randomization study.

ABSTRACT:

Background

Many studies have investigated the association between hypothyroidism and frozen shoulder, but their findings have been inconsistent. Furthermore, earlier research has been primarily observational, which may introduce bias and does not establish a cause-and-effect relationship. To ascertain the causal association, we performed a two-sample bidirectional Mendelian randomization (MR) analysis.

Methods

We obtained data on "Hypothyroidism" and "Frozen Shoulder" from Summary-level Genome-Wide Association Studies (GWAS) datasets that have been published. The information came from European population samples. The primary analysis utilized the inverse-variance weighted (IVW) method. Additionally, a sensitivity analysis was conducted to assess the robustness of the results

SUBMITTER: Chen B 

PROVIDER: S-EPMC11367819 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature