Proteomic changes at 8 weeks after infection are associated with chronic liver pathology in experimental schistosomiasis.

ABSTRACT: Chronic Schistosoma mansoni infection can present as a moderate or severe disease, termed intestinal or hepatosplenic schistosomiasis, respectively. Similarly, either moderate splenomegaly or hypersplenomegaly syndrome develops in CBA/J mice by 20weeks of infection and is similar to intestinal or hepatosplenic schistosomiasis respectively. Using this mouse model and two-dimensional differential in gel electrophoresis, the liver proteomic signatures of uninfected mice and mice infected for 6, 8, 12, or 20weeks were compared, and significant protein spots identified using mass spectrometry. We found the greatest number of changes at 12weeks suggesting that this period represents the peak time of change. Pathway analysis identified specific proteins and pathways that correlated to the patholo

SUBMITTER: Manivannan B 

PROVIDER: S-EPMC11367832 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature