Antimalarial drug sulfadoxine induces gametocytogenesis in Plasmodium berghei.

ABSTRACT:

Background

The spread of antimalarial drug resistance parasites is a major obstacle in eliminating malaria in endemic areas. This increases the urgency for developing novel antimalarial drugs with improved profiles to eliminate both sensitive and resistant parasites in populations. The invention of the drug candidates needs a model for sensitive and resistant parasites on a laboratory scale.

Methods

Repeated Incomplete Treatment (RIcT) method was followed in raising the rodent malaria parasite, Plasmodium berghei, resistant to sulfadoxine. Plasmodium berghei were exposed to an adequate therapeutic dose of sulfadoxine without finishing the treatment to let the parasite recover. Cycles of drug treatment and parasite recovery were repeated until phenotypic resistance appeared.<

SUBMITTER: Azmi WA 

PROVIDER: S-EPMC11367840 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature