Polygenic risk score portability for common diseases across genetically diverse populations.

ABSTRACT:

Background

Polygenic risk scores (PRS) derived from European individuals have reduced portability across global populations, limiting their clinical implementation at worldwide scale. Here, we investigate the performance of a wide range of PRS models across four ancestry groups (Africans, Europeans, East Asians, and South Asians) for 14 conditions of high-medical interest.

Methods

To select the best-performing model per trait, we first compared PRS performances for publicly available scores, and constructed new models using different methods (LDpred2, PRS-CSx and SNPnet). We used 285 K European individuals from the UK Biobank (UKBB) for training and 18 K, including diverse ancestries, for testing. We then evaluated PRS portability for the best models in Europeans and compare

SUBMITTER: Moreno-Grau S 

PROVIDER: S-EPMC11367857 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature