Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals.

ABSTRACT:

Background

Limited data exists regarding gender-specific microbial alterations during gender-affirming hormonal therapy (GAHT) in transgender individuals. This study aimed to investigate the nuanced impact of sex steroids on gut microbiota taxonomy and function, addressing this gap. We prospectively analyzed gut metagenome changes associated with 12 weeks of GAHT in trans women and trans men, examining both taxonomic and functional shifts.

Methods

Thirty-six transgender individuals (17 trans women, 19 trans men) provided pre- and post-GAHT stool samples. Shotgun metagenomic sequencing was used to assess the changes in gut microbiota structure and potential function following GAHT.

Results

While alpha and beta diversity remained unchanged during transition, specific sp

SUBMITTER: Liwinski T 

PROVIDER: S-EPMC11367877 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature