CHIKV infection drives shifts in the gastrointestinal microbiome and metabolites in rhesus monkeys.

ABSTRACT:

Background

Many studies have demonstrated the association between intestinal microbiota and joint diseases. The "gut-joint axis" also has potential roles in chikungunya virus (CHIKV) infection. Pro-inflammatory arthritis after CHIKV infection might disrupt host homeostasis and lead to dysbacteriosis. This study investigated the characteristics of fecal and gut microbiota, intestinal metabolites, and the changes in gene regulation of intestinal tissues after CHIKV infection using multi-omics analysis to explore the involvement of gut microbiota in the pathogenesis of CHIKV infection.

Results

CHIKV infection increases the systemic burden of inflammation in the GI system of infected animals. Moreover, infection-induced alterations in GI microbiota and metabolites may be indirec

SUBMITTER: Chen H 

PROVIDER: S-EPMC11367899 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature