Whole-genome de novo sequencing reveals genomic variants associated with differences of sex development in SRY negative pigs.

ABSTRACT:

Background

Differences of sex development (DSD) are congenital conditions in which chromosomal, gonadal, or phenotypic sex is atypical. In more than 50% of human DSD cases, a molecular diagnosis is not available. In intensively farmed pig populations, the incidence of XX DSD pigs is relatively high, leading to economic losses for pig breeders. Interestingly, in the majority of 38, XX DSD pigs, gonads still develop into testis-like structures or ovotestes despite the absence of the testis-determining gene (SRY). However, the current understanding of the molecular background of XX DSD pigs remains limited.

Methods

Anatomical and histological characteristics of XX DSD pigs were analysed using necropsy and HE staining. We employed whole-genome sequencing (WGS) with 10× Genomics

SUBMITTER: Wu J 

PROVIDER: S-EPMC11367908 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature