Alterations of pleiotropic neuropeptide-receptor gene couples in Cetacea.

ABSTRACT:

Background

Habitat transitions have considerable consequences in organism homeostasis, as they require the adjustment of several concurrent physiological compartments to maintain stability and adapt to a changing environment. Within the range of molecules with a crucial role in the regulation of different physiological processes, neuropeptides are key agents. Here, we examined the coding status of several neuropeptides and their receptors with pleiotropic activity in Cetacea.

Results

Analysis of 202 mammalian genomes, including 41 species of Cetacea, exposed an intricate mutational landscape compatible with gene sequence modification and loss. Specifically for Cetacea, in the 12 genes analysed we have determined patterns of loss ranging from species-specific disruptive mutat

SUBMITTER: Valente R 

PROVIDER: S-EPMC11367936 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature