Endogenous electric field coupling Mxene sponge for diabetic wound management: haemostatic, antibacterial, and healing.

ABSTRACT: Improper management of diabetic wound effusion and disruption of the endogenous electric field can lead to passive healing of damaged tissue, affecting the process of tissue cascade repair. This study developed an extracellular matrix sponge scaffold (K₁P₆@Mxene) by incorporating Mxene into an acellular dermal stroma-hydroxypropyl chitosan interpenetrating network structure. This scaffold is designed to couple with the endogenous electric field and promote precise tissue remodelling in diabetic wounds. The fibrous structure of the sponge closely resembles that of a natural extracellular matrix, providing a conducive microenvironment for cells to adhere grow, and exchange oxygen. Additionally, the inclusion of Mxene enhances antibacterial activity(98.89%) and electrica

SUBMITTER: Zhou H 

PROVIDER: S-EPMC11367980 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature