Acute and chronic ocular outcomes in SJS/TEN patients treated with oral ciclosporin vs intravenous immunoglobulin.

ABSTRACT:

Background/aim

To evaluate differences in ocular complications of Stevens Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN) patients receiving either systemic IVIG or Ciclosporin (CsA) as initial treatments.

Methods

Retrospective review of consecutive patients admitted for SJS/TEN at the Singapore General Hospital (SGH) from 2011 to 2017 who received either IVIG or Ciclosporin at the onset of the disease and had ophthalmological follow-up of at least 6 months were included. Acute ocular severity of SJS/TEN was graded using the Gregory grading score; chronic ocular complications were graded using the Sotozono system.

Results

A total of 18 subjects were included for analysis, with eight in the IVIG group and 10 in the CsA group. There were no significant differenc

SUBMITTER: Foo VHX 

PROVIDER: S-EPMC11368074 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature