Influence of angiotensin II on the gut microbiome: modest effects in comparison to experimental factors.

ABSTRACT:

Aims

Animal models are regularly used to test the role of the gut microbiome in hypertension. Small-scale pre-clinical studies have investigated changes to the gut microbiome in the angiotensin II hypertensive model. However, the gut microbiome is influenced by internal and external experimental factors, which are not regularly considered in the study design. Once these factors are accounted for, it is unclear if microbiome signatures are reproduceable. We aimed to determine the influence of angiotensin II treatment on the gut microbiome using a large and diverse cohort of mice and to quantify the magnitude by which other factors contribute to microbiome variations.

Methods and results

We conducted a retrospective study to establish a diverse mouse cohort resembling large hu

SUBMITTER: R Muralitharan R 

PROVIDER: S-EPMC11368123 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature