Depth detection limit of a fluorescent object in tissue-like medium with background emission in continuous-wave measurements: a phantom study.

ABSTRACT:

Significance

Although the depth detection limit of fluorescence objects in tissue has been studied, reports with a model including noise statistics for designing the optimum measurement configuration are missing. We demonstrate a variance analysis of the depth detection limit toward clinical applications such as noninvasively assessing the risk of aspiration.

Aim

It is essential to analyze how the depth detection limit of the fluorescence object in a strong scattering medium depends on the measurement configuration to optimize the configuration. We aim to evaluate the depth detection limit from theoretical analysis and phantom experiments and discuss the source-detector distance that maximizes this limit.

Approach

Experiments for detecting a fluorescent object in a bi

SUBMITTER: Nishimura G 

PROVIDER: S-EPMC11368132 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature