Different patterns of structural network impairments in two amyotrophic lateral sclerosis subtypes driven by ¹⁸F-fluorodeoxyglucose positron emission tomography/magnetic resonance hybrid imaging.

ABSTRACT: The structural network damages in amyotrophic lateral sclerosis patients are evident but contradictory due to the high heterogeneity of the disease. We hypothesized that patterns of structural network impairments would be different in amyotrophic lateral sclerosis subtypes by a data-driven method using ¹⁸F-fluorodeoxyglucose positron emission tomography/magnetic resonance hybrid imaging. The data of positron emission tomography, structural MRI and diffusion tensor imaging in fifty patients with amyotrophic lateral sclerosis and 23 healthy controls were collected by a ¹⁸F-fluorodeoxyglucose positron emission tomography/magnetic resonance hybrid. Two amyotrophic lateral sclerosis subtypes were identified as the optimal cluster based on grey matter volume and standardize

SUBMITTER: Feng F 

PROVIDER: S-EPMC11368155 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature