HIV-1 transmitted drug resistance in newly diagnosed individuals in Italy over the period 2015-21.

ABSTRACT:

Background

Transmitted drug resistance (TDR) is still a critical aspect for the management of individuals living with HIV-1. Thus, its evaluation is crucial to optimize HIV care.

Methods

Overall, 2386 HIV-1 protease/reverse transcriptase and 1831 integrase sequences from drug-naïve individuals diagnosed in north and central Italy between 2015 and 2021 were analysed. TDR was evaluated over time. Phylogeny was generated by maximum likelihood. Factors associated with TDR were evaluated by logistic regression.

Results

Individuals were mainly male (79.1%) and Italian (56.2%), with a median (IQR) age of 38 (30-48). Non-B infected individuals accounted for 44.6% (N = 1065) of the overall population and increased over time (2015-2021, from 42.1% to 51.0%, P = 0.002). TDR prev

SUBMITTER: Fabeni L 

PROVIDER: S-EPMC11368429 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature