Strathclyde minor groove binders (S-MGBs) with activity against Acanthamoeba castellanii.

ABSTRACT:

Background

Acanthamoeba spp. is the causative agent of Acanthamoeba keratitis and granulomatous amoebic encephalitis. Strathclyde minor groove binders (S-MGBs) are a promising new class of anti-infective agent that have been shown to be effective against many infectious organisms.

Objectives

To synthesize and evaluate the anti-Acanthamoeba activity of a panel of S-MGBs, and therefore determine the potential of this class for further development.

Methods

A panel of 12 S-MGBs was synthesized and anti-Acanthamoeba activity was determined using an alamarBlue™-based trophocidal assay against Acanthamoeba castellanii. Cross-screening against Trypanosoma brucei brucei, Staphylococcus aureus and Escherichia coli was used to investigate selective potency. Cytotoxicity against

SUBMITTER: Mcgee LMC 

PROVIDER: S-EPMC11368431 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature