Impact of perioperative prognostic nutritional index changes on the survival of patients with stage II/III colorectal cancer.

ABSTRACT:

Aim

To assess the impact of perioperative prognostic nutritional index (PNI) changes on prognosis and recurrence after colorectal cancer surgery.

Methods

A total of 475 patients who underwent curative resection for primary colorectal adenocarcinoma and were diagnosed with pathological stage (pStage) II/III were retrospectively reviewed. The patients were divided into two groups: the high group (preoperative PNI ≤ postoperative PNI, n = 290) and the low group (preoperative PNI > postoperative PNI, n = 185).

Results

The low group exhibited significantly higher recurrence and mortality rates (all p < 0.001). Kaplan-Meier analysis showed worse overall and recurrence-free survival in the low group (all p < 0.001). Perioperative PNI changes predi

SUBMITTER: Tatsuta K 

PROVIDER: S-EPMC11368507 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature