Dataset Information
The impact of consanguinity on the design of iPSC banks.
Ontology highlight
ABSTRACT:
SUBMITTER: Alkuraya IF
PROVIDER: S-EPMC11368693 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Publications
The impact of consanguinity on the design of iPSC banks.
Stem cell reports 20240711 8
The effect of consanguinity on identifying universal induced pluripotent stem cell (iPSC) donors, i.e., homozygous for the major human leukocyte antigen (HLA) loci, is unknown. The discovery sample size was calculated in a consanguineous population using a method (1qF) based on the inbreeding coefficient. The result was orders of magnitude smaller compared to the standard method. ...[more]