Comprehensive landscapes of the causal network between immunity and sarcopenia.

ABSTRACT:

Background

Inflammaging, an immune status characterized by a sustained increase in pro-inflammatory markers and a decline in anti-inflammatory mechanisms, is a critical risk factor in the development of sarcopenia. Landscapes of the causal relationships between immunity and sarcopenia are needed to understand the mechanism of sarcopenia and provide novel treatments comprehensively.

Methods

We used Mendelian Randomization (MR) as the basic method in this study. By setting immune proteins, immune cells, and sarcopenia as exposures and outcomes alternatively, and then combining them in different directions, we potentially estimated their causal relationships and directions and subsequently mapped the comprehensive causal landscape based on this information efficiently. To furth

SUBMITTER: Liu M 

PROVIDER: S-EPMC11368746 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature