Oxidative stress mediates the association between triglyceride-glucose index and risk of cardiovascular and all-cause mortality in metabolic syndrome: evidence from a prospective cohort study.

ABSTRACT:

Background

The aim of this study was to investigate the relationship between triglyceride-glucose (TyG) index and cardiovascular disease (CVD) and all-cause mortality in adults with metabolic syndrome (MeS) and explore the mediating role of oxidative stress.

Methods

This study included 6131 adults with MeS from the National Health and Nutrition Examination Survey (NHANES). The relationships between TyG index and mortality were elucidated using multivariate Cox proportional hazards models, restricted cubic splines (RCS) Fine-Gray competing risk model. In addition, mediation analysis was used to test the indirect effect of oxidative stress indicators.

Results

Over a median 106-month follow-up, a total of 357 CVD and 1292 all-cause deaths were recorded. After multivariat

SUBMITTER: Yang M 

PROVIDER: S-EPMC11368748 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature