Impact of <i>E. muris</i> infection on <i>B. burgdorferi-</i>induced joint pathology in mice.

ABSTRACT: Tick-borne infections are increasing in the United States and around the world. The most common tick-borne disease in the United States is Lyme disease caused by infection with the spirochete Borrelia burgdorferi (Bb), and pathogenesis varies from subclinical to severe. Bb infection is transmitted by Ixodes ticks, which can carry multiple other microbial pathogens, including Ehrlichia species. To address how the simultaneous inoculation of a distinct pathogen impacted the course of Bb-induced disease, we used C57BL/6 (B6) mice which are susceptible to Bb infection but develop only mild joint pathology. While infection of B6 mice with Bb alone resulted in minimal inflammatory responses, mice co-infected with both Bb and the obli

SUBMITTER: Bonin JL 

PROVIDER: S-EPMC11368855 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature