Pre-therapy PET-based voxel-wise dosimetry prediction by characterizing intra-organ heterogeneity in PSMA-directed radiopharmaceutical theranostics.

ABSTRACT:

Background and objective

Treatment planning through the diagnostic dimension of theranostics provides insights into predicting the absorbed dose of RPT, with the potential to individualize radiation doses for enhancing treatment efficacy. However, existing studies focusing on dose prediction from diagnostic data often rely on organ-level estimations, overlooking intra-organ variations. This study aims to characterize the intra-organ theranostic heterogeneity and utilize artificial intelligence techniques to localize them, i.e. to predict voxel-wise absorbed dose map based on pre-therapy PET.

Methods

23 patients with metastatic castration-resistant prostate cancer treated with [¹⁷⁷Lu]Lu-PSMA I&T RPT were retrospectively included. 48 treatment cycles with pre-treatm

SUBMITTER: Xue S 

PROVIDER: S-EPMC11368979 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature