Assessment of cerebral drug occupancy in humans using a single PET-scan: A [¹¹C]UCB-J PET study.

ABSTRACT:

Purpose

Here, we evaluate a PET displacement model with a Single-step and Numerical solution in healthy individuals using the synaptic vesicle glycoprotein (SV2A) PET-tracer [¹¹C]UCB-J and the anti-seizure medication levetiracetam (LEV). We aimed to (1) validate the displacement model by comparing the brain LEV-SV2A occupancy from a single PET scan with the occupancy derived from two PET scans and the Lassen plot and (2) determine the plasma LEV concentration-SV2A occupancy curve in healthy individuals.

Methods

Eleven healthy individuals (five females, mean age 35.5 [range: 25-47] years) underwent two 120-min [¹¹C]UCB-J PET scans where an LEV dose (5-30 mg/kg) was administered intravenously halfway through the first PET scan to partially displace radiol

SUBMITTER: Marstrand-Joergensen MR 

PROVIDER: S-EPMC11369007 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature