Excess mortality in patients with non-functioning pituitary adenoma: a systematic review and meta-analysis.

ABSTRACT:

Background

Patients with non-functioning pituitary adenoma (NFPA) often present with a variety of clinical manifestations and comorbidities, mainly determined by the local mass effect of the tumor and by hypopituitarism. Whether this has an impact on overall mortality, however, is still unclear.

Methods

PubMed/Medline, EMBASE, and Cochrane Library databases were systematically searched until May 2023 for studies reporting data either about standardized mortality ratios (SMRs) or about predictors of mortality in patients with NFPA. Effect sizes were pooled through a random-effect model. This systematic review and meta-analysis was registered in the International Prospective Register of Systematic Reviews (PROSPERO, #CRD42023417782).

Results

Eleven studies were eligible

SUBMITTER: Bioletto F 

PROVIDER: S-EPMC11369010 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature