Establishment and evaluation of an improved rat model of open abdomen.

ABSTRACT:

Introduction

This study aimed to establish an animal model of open abdomen (OA) through temporary abdominal closure via different techniques.

Methods

Adult male Sprague-Dawley rats were randomly divided into three groups: group A (OA with polypropylene mesh alone); group B (OA with polypropylene mesh combined with a patch); and group C (OA with polypropylene mesh and a sutured patch). Vital signs, pathophysiological changes, and survival rates were closely monitored in the rats for 7 days after surgery. Abdominal X-rays and histopathological examinations were performed to assess abdominal organ changes and wound healing.

Results

The results showed no significant difference in mortality rates among the three groups (p > 0.05). However, rats in group B exhibited superio

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11369015 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature