Assessment of the piroxicam-incited model of synchronized colitis in T-cell receptor alpha chain-deficient mice.

ABSTRACT:

Background

A multitude of mouse models are utilized to emulate and study intestinal inflammation. T-cell receptor alpha chain (TCRα)-deficient mice are used as a model of spontaneous colitis that has similarities with human ulcerative colitis. However, colitis is triggered late in the life of the mouse (age: 4-5 months), and inflammation does not develop at the same time in different mice. A previously conducted study reported that the administration of the drug piroxicam triggered predictable and early colitis in TCRα-deficient mice at the age of 6-8 weeks. However, a detailed characterization of ensuing inflammation was not provided.

Methods

We conducted an in-depth examination of piroxicam-triggered colitis in TCRα-deficient mice, with emphasis on spatial histopathologic

SUBMITTER: Lange ME 

PROVIDER: S-EPMC11369028 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature