Preliminary study of metabonomic changes during the progression of atherosclerosis in miniature pigs.

ABSTRACT:

Background

To explore potential biomarkers for early diagnosis of atherosclerosis (AS) and provide basic data for further research on AS, the characteristics of serum metabolomics during the progression of AS in mini-pigs were observed dynamically.

Methods

An AS model in Bama miniature pigs was established by a high-cholesterol and high-fat diet. Fasting serum samples were collected monthly for metabolomics and serum lipid detection. At the end of the treatment period, pathological analysis of the abdominal aorta and coronary artery was performed to evaluate the lesions of AS, thereby distinguishing the susceptibility of mini-pigs to AS. The metabolomics was detected using a high-resolution untargeted metabolomic approach. Statistical analysis was used to identify metabolite

SUBMITTER: Jia Y 

PROVIDER: S-EPMC11369038 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature